Liverpool blijft ook na vijf speelrondes de onbetwiste koploper in de Premier League. De ploeg van Jürgen Klopp won de Merseyside-derby tegen Everton met 2-1 en blijft daarmee foutloos. Achtervolgers Arsenal en Tottenham morsten punten, waardoor de voorsprong van de Reds groeit. Onderaan blijft het crisis bij Wolverhampton Wanderers, dat nog altijd puntloos is.
| Datum | Wedstrijd | Uitslag |
|---|---|---|
| 20/09/2025 | Liverpool FC – Everton FC | 2-1 |
| 20/09/2025 | Brighton & Hove Albion – Tottenham Hotspur | 2-2 |
| 20/09/2025 | Burnley FC – Nottingham Forest | 1-1 |
| 20/09/2025 | West Ham United – Crystal Palace | 1-2 |
| 20/09/2025 | Wolverhampton Wanderers – Leeds United | 1-3 |
| 20/09/2025 | Manchester United – Chelsea FC | 2-1 |
| 20/09/2025 | Fulham FC – Brentford FC | 3-1 |
| 21/09/2025 | Sunderland AFC – Aston Villa FC | 1-1 |
| 21/09/2025 | AFC Bournemouth – Newcastle United FC | 0-0 |
| 21/09/2025 | Arsenal FC – Manchester City FC | 1-1 |
| Positie | Team | P | W | D | L | F | A | +/- | PTS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver pool |
5 | 5 | 0 | 0 | 11 | 5 | 6 | 15 | ||
| 2 |  Arsenaal |
5 | 3 | 1 | 1 | 10 | 2 | 8 | 10 | ||
| 3 |  Tottenham |
5 | 3 | 1 | 1 | 10 | 3 | 7 | 10 | ||
| 4 |  Bournemouth |
5 | 3 | 1 | 1 | 6 | 5 | 1 | 10 | ||
| 5 |  Crystal palace |
5 | 2 | 3 | 0 | 6 | 2 | 4 | 9 | ||
| 6 |  Chelsea |
5 | 2 | 2 | 1 | 10 | 5 | 5 | 8 | ||
| 7 |  Sunderland |
5 | 2 | 2 | 1 | 6 | 4 | 2 | 8 | ||
| 8 |  Fulham |
5 | 2 | 2 | 1 | 6 | 5 | 1 | 8 | ||
| 9 |  Manchester City |
5 | 2 | 1 | 2 | 9 | 5 | 4 | 7 | ||
| 10 |  Everton |
5 | 2 | 1 | 2 | 6 | 5 | 1 | 7 | ||
| 11 |  Manchester United |
5 | 2 | 1 | 2 | 6 | 8 | -2 | 7 | ||
| 12 |  Leeds |
5 | 2 | 1 | 2 | 4 | 7 | -3 | 7 | ||
| 13 |  Newcastle United |
5 | 1 | 3 | 1 | 3 | 3 | 0 | 6 | ||
| 14 |  Brighton |
5 | 1 | 2 | 2 | 6 | 8 | -2 | 5 | ||
| 15 |  Nottingham Forest |
5 | 1 | 2 | 2 | 5 | 9 | -4 | 5 | ||
| 16 |  Burnley |
5 | 1 | 1 | 3 | 5 | 8 | -3 | 4 | ||
| 17 |  Brentford |
5 | 1 | 1 | 3 | 6 | 10 | -4 | 4 | ||
| 18 |  Aston Villa |
5 | 0 | 3 | 2 | 1 | 5 | -4 | 3 | ||
| 19 |  West Ham |
5 | 1 | 0 | 4 | 5 | 13 | -8 | 3 | ||
| 20 |  Wolverhampton Wanderers |
5 | 0 | 0 | 5 | 3 | 12 | -9 | 0 |
