| Anji |  |
0-0 |  |
AZ |
| Aggregate: 0-1 | ||||
| Referee: Craig Thomson (SCO)Ā Ā ā Stadium: Saturn, Ramenskoye (RUS) | ||||
| Valencia |  |
1-0 |  |
Ludogorets |
| Aggregate: 4-0 | ||||
| Referee: Tasos Sidiropoulos (GRE)Ā Ā ā Stadium: Estadi de Mestalla, Valencia (ESP) | ||||
| Fiorentina |  |
0-1 |  |
Juventus |
| Aggregate: 1-2 | ||||
| Referee: Howard Webb (ENG)Ā Ā ā Stadium: Stadio Artemio Franchi, Florence (ITA) | ||||
| PlzeÅ |  |
2-1 |  |
Lyon |
| Aggregate: 3-5 | ||||
| Referee: Szymon Marciniak (POL)Ā Ā ā Stadium: Å truncovy Sady StadiĆ³n, Plzen (CZE) | ||||
| Benfica |  |
2-2 |  |
Tottenham |
| Aggregate: 5-3 | ||||
| Referee: Damir Skomina (SVN)Ā Ā ā Stadium: EstĆ”dio do Sport Lisboa e Benfica, Lisbon (POR) | ||||
| Salzburg |  |
1-2 |  |
Basel |
| Aggregate: 1-2 | ||||
| Referee: Manuel GrƤfe (GER)Ā Ā ā Stadium: Stadion Salzburg, Salzburg (AUT) | ||||
| Betis |  |
0-2 |  |
Sevilla |
| Aggregate: 2-2 Sevilla winĀ 4-3Ā on penalties | ||||
| Referee: Pedro ProenƧa (POR)Ā Ā ā Stadium: Benito VillamarĆn, Seville (ESP) | ||||
| Napoli |  |
2-2 |  |
Porto |
| Aggregate: 2-3 | ||||
| Referee: Martin Atkinson (ENG)Ā Ā ā Stadium: Stadio San Paolo, Naples (ITA) | ||||
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