| Anji |  |
0-0 |  |
AZ |
| Aggregate: 0-1 | ||||
| Referee: Craig Thomson (SCO) – Stadium: Saturn, Ramenskoye (RUS) | ||||
| Valencia |  |
1-0 |  |
Ludogorets |
| Aggregate: 4-0 | ||||
| Referee: Tasos Sidiropoulos (GRE) – Stadium: Estadi de Mestalla, Valencia (ESP) | ||||
| Fiorentina |  |
0-1 |  |
Juventus |
| Aggregate: 1-2 | ||||
| Referee: Howard Webb (ENG) – Stadium: Stadio Artemio Franchi, Florence (ITA) | ||||
| Plzeň |  |
2-1 |  |
Lyon |
| Aggregate: 3-5 | ||||
| Referee: Szymon Marciniak (POL) – Stadium: Štruncovy Sady Stadión, Plzen (CZE) | ||||
| Benfica |  |
2-2 |  |
Tottenham |
| Aggregate: 5-3 | ||||
| Referee: Damir Skomina (SVN) – Stadium: Estádio do Sport Lisboa e Benfica, Lisbon (POR) | ||||
| Salzburg |  |
1-2 |  |
Basel |
| Aggregate: 1-2 | ||||
| Referee: Manuel Gräfe (GER) – Stadium: Stadion Salzburg, Salzburg (AUT) | ||||
| Betis |  |
0-2 |  |
Sevilla |
| Aggregate: 2-2 Sevilla win 4-3 on penalties | ||||
| Referee: Pedro Proença (POR) – Stadium: Benito Villamarín, Seville (ESP) | ||||
| Napoli |  |
2-2 |  |
Porto |
| Aggregate: 2-3 | ||||
| Referee: Martin Atkinson (ENG) – Stadium: Stadio San Paolo, Naples (ITA) | ||||
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